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目的:探讨宫颈癌放疗后下肢深静脉血栓的发生率、发生时间及影响因素。方法:回顾性分析2008-2011年在我院行体外照射加~(252)Cf中子腔内根治性放疗的宫颈癌病例,共516例。分析下肢深静脉的发生率和发生中位时间,单因素分析同步化疗、临床分期、年龄、血清D-二聚体与下肢深静脉血栓形成的关系以及治疗效果。结果:共发生下肢静脉血栓12例,发生率为2.33%。下肢深静脉血栓的中位年龄为45岁。放疗后至确诊发生严重深部静脉血栓的中位时间为6个月。单因素分析结果显示年龄和临床分期在有血栓和无血栓组间差异无统计学意义,而是否行同步化疗差异显著(P=0.022)。结论:宫颈癌放疗后可能出现有明显临床症状的下肢深静脉血栓,血栓的发生与患者的年龄和临床分期无明显相关,但同步化疗可能增加血栓的发生。
Objective: To investigate the incidence, time and influential factors of lower extremity deep venous thrombosis after radiotherapy for cervical cancer. Methods: A total of 516 cases of cervical cancer with radical radiotherapy of ~ (252) Cf neutron cavity in our hospital from 2008 to 2011 were retrospectively analyzed. Analysis of the incidence of deep venous and the median time of occurrence, single factor analysis of synchronous chemotherapy, clinical stage, age, serum D-dimer and deep vein thrombosis and the therapeutic effect. Results: There were 12 cases of venous thrombosis of the lower extremity, the incidence was 2.33%. The median age of lower extremity DVT was 45 years. Radiotherapy to the diagnosis of severe deep venous thrombosis after the median time of 6 months. Univariate analysis showed that there was no significant difference in age and clinical stage between thrombosed and thromboembolic groups, but there was significant difference (P = 0.022) between the two groups. Conclusion: Cervical cancer may have obvious clinical symptoms of lower extremity deep venous thrombosis after radiotherapy. There is no significant correlation between thrombosis and age and clinical stage of patients. However, concurrent chemotherapy may increase the incidence of thrombosis.