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目的 了解脑梗死患者血清IL - 1β、sICAM - 1含量在急性期和恢复期的变化及意义。 方法 运用酶联免疫吸附法 (ELISA)测定血清中IL - 1β、sICAM - 1含量。 结果 急性期、恢复期脑梗死患者血清IL - 1β、sICAM - 1水平均较对照组显著增高 (P <0 .0 1,P <0 .0 1;P <0 .0 1,P <0 .0 5 ) ,急性期又较恢复期明显增高 (P <0 .0 1,P <0 .0 5 ) ,两者增高程度与梗死灶大小密切相关 ;且急性期脑梗死患者sICAM - 1的水平与IL - 1β的水平呈正相关 (r =0 .6 9,P <0 .0 0 1) ,恢复期脑梗死患者的sICAM - 1与IL - 1β呈正相关 (r =0 .48,P <0 .0 1)。结论 IL - 1β、ICAM - 1可能参与了脑梗死早期的炎症反应及再灌注损伤 ,临床脑梗死I CAM - 1表达上调可能与炎性细胞因子IL - 1β有关
Objective To investigate the changes and significance of serum IL - 1β and sICAM - 1 levels in acute and convalescent patients with cerebral infarction. Methods Serum levels of IL - 1β and sICAM - 1 were measured by enzyme - linked immunosorbent assay (ELISA). Results The serum levels of IL - 1β and sICAM - 1 in acute and convalescent cerebral infarction patients were significantly higher than those in control group (P <0.01, P <0.01; P <0.01, P <0.01). 0 5). The acute phase was significantly higher than that of convalescent phase (P <0.01, P <0.05), both of which were closely related to the infarct size. The levels of sICAM - 1 in patients with acute cerebral infarction (R = 0.48, P <0.01). There was a positive correlation between sICAM - 1 and IL - 1β in patients with convalescent cerebral infarction (r = 0.48, P <0 .0 1). Conclusion IL - 1β and ICAM - 1 may be involved in the inflammatory reaction and reperfusion injury in early stage of cerebral infarction. The up - regulation of I CAM - 1 may contribute to the inflammatory cytokine IL - 1β