合并应用异山梨醇-5-单硝酸酯(ISMN)可以增强心得安降低门脉高压的作用。但对心得安、ISMN长期合并应用是否会明显改变血液动力学并由此产生肾功能改变则尚不明。本研究目的为解答此问题。选择30例各种病因所致的肝硬化病人,均在食管静脉曲张破裂出血停止后进入试验,18/30例当时有腹水,其中14例还用利尿剂治疗(试验期间停用利尿 Combination of isosorbide-5-mononitrate (ISMN) can enhance the role of prednisolone portal hypertension. However, it is not yet clear whether or not long-term ISMN administration will significantly alter hemodynamics and consequently renal function. The purpose of this study is to answer this question. Thirty patients with cirrhosis due to various etiologies were enrolled in the trial after esophageal variceal bleeding was discontinued. Ascites was present in 18 of 30 patients, of whom 14 were also treated with diuretics (diuresis was discontinued during the trial