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癌症已成为全球头号杀手,迫切需要从自然界寻找更新、更有效的抗肿瘤药物。植物内生真菌是指生活在宿主植物体内,不会对宿主植物组织引起明显病害症状的一类真菌。众多研究表明,植物内生真菌在寻找抗肿瘤药物中起着至关重要的作用。随着植物内生真菌研究的深入,从植物内生真菌中寻找新的抗肿瘤活性成分已成为研究的热点。大量的抗肿瘤活性成分从植物内生真菌中分离出来,并表现出良好的抗肿瘤活性。目前,植物内生真菌抗肿瘤活性代谢产物主要有紫杉醇、喜树碱、长春新碱,鬼臼毒素等等,本文主要对近年来植物内生真菌抗肿瘤活性成分的研究进展进行了综述。
Cancer has become the world’s number one killer, there is an urgent need to look for newer and more effective antitumor drugs in nature. Endophytic fungi are a group of fungi that live in host plants and do not cause significant disease symptoms to host plant tissues. Numerous studies show that plant endophytic fungi play a crucial role in finding anti-tumor drugs. With the deepening of plant endophytic fungi research, looking for new anti-tumor active ingredients from plant endophytic fungi has become a hot spot. A large number of anti-tumor active ingredients isolated from endophytic fungi plant, and showed good anti-tumor activity. At present, the main anti-tumor bioactive metabolites of plant endophytic fungi are paclitaxel, camptothecin, vincristine, podophyllotoxin, etc. In this paper, the research progress on anti-tumor active components of plant endophytic fungi in recent years are reviewed.