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对犬和兔的冠状动脉分别形成不同程度的机械性狭窄和药物性痉挛1小时,观察冠状动脉狭窄后急性心肌缺血的早期形态学改变,探讨其形态学诊断标准。结果表明:光镜下急性早期缺血性改变为心肌细胞嗜伊红增强和较具特征性的心肌纤维波浪状变和收缩带形成。轻度波浪状变电镜下仅见轻度线粒体肿胀;重度波浪状变线粒体肿胀明显,嵴断裂、溶解消失、空泡变,肌原纤维肿胀、变性或断裂。波浪状变和收缩带并存时,Z线增宽,肌节呈节段性疑聚,形成典型之“竹根样”或“竹节样”改变。作者认为,轻度心肌纤维波浪状变不足以说明为心肌缺血性改变;重度波浪状变可作为早期心肌缺血的形态学指标;若波浪状变同时伴有收缩带形成时,表明心肌缺血程度严重。
The canine and rabbit coronary arteries were formed to varying degrees of mechanical stenosis and drug-induced spasms for 1 hour respectively. The early morphological changes of acute myocardial ischemia after coronary stenosis were observed, and their morphological diagnostic criteria were discussed. The results showed that the acute ischemic changes under light microscopy were enhanced eosinophil cardiomyocytes and the more characteristic myocardial fibers wavy deformation and contraction zone formation. Mild wavy electron microscopy showed only mild mitochondrial swelling; severe wavy mitochondrial mitochondria showed obvious swelling, crest fracture, dissolution disappeared, vacuolar changes, myofibrillar swelling, degeneration or rupture. Wavy deformation and contraction co-exist, the Z line broadening, sarcomere segmented suspicion, the formation of a typical “bamboo-like” or “bamboo-like” changes. The author believes that mild myocardial fiber wavy change is not enough to explain changes in myocardial ischemia; severe wavy change can be used as a morphological indicator of early myocardial ischemia; wavy change accompanied by the formation of contractile bands, indicating lack of myocardium Serious blood.