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睾丸生殖细胞癌主要累及青壮年。其中20～30岁的男性人群癌形成最为常见。并且其发病率似乎正逐年递增。目前,非精原细胞瘤患者的85%和精原细胞癌患者的95%经过合理的治疗后,已能存活很长的时间。然而,上述治疗可能影响患者的生育力,并且会带来突变频率增加的风险,这些突变有可能传递给他们的子女。本文报道了作者对4例睾丸癌患者在治疗后,化疗对精子功能和染色体结构的远期效应的研究结果。从4例2～7年前接受化疗的睾丸癌患者中取得精液标本。采用稍加改进的人精子
Testicular germ cell cancer mainly affects young adults. Including 20 to 30-year-old male cancer is most common. And its incidence appears to be increasing year by year. Currently, 85% of patients with non-seminoma and 95% of patients with spermatogonia are well treated and have been able to survive for a long time. However, the above treatments may affect the patient’s fertility and raise the risk of an increased frequency of mutations that are likely to be passed on to their children. This article reports the results of the authors investigating the long-term effects of chemotherapy on sperm function and chromosomal structure in 4 patients with testicular cancer after treatment. Semen samples were obtained from 4 patients with testicular cancer who received chemotherapy between 2 and 7 years ago. Slightly improved human sperm