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[目的]探讨血清鸢尾素(Irisin)水平与不同非酒精性脂肪性肝病(NAFLD)病变程度的相关性。[方法]选取我院2014年11月~2015年12月收治的NAFLD患者140例作为研究对象,根据患者病变严重程度,将患者分为轻度、中度、重度、极重病变程度组。另选取同期我院健康体检者148例作为对照组,收集2组患者的实验室检查资料及一般资料进行分析,探讨Irisin水平与不同NAFLD病变程度的相关性。[结果]观察组患者总胆固醇、甘油三酯、AST、ALT、血清Irisin、收缩压、舒张压、腰围、臀围、空腹血糖、空腹胰岛素、HOM-IR水平明显高于对照组健康体检者,差异有统计学意义(P<0.05);总胆固醇、甘油三酯、血清Irisin、AST、空腹血糖、空腹胰岛素、HOM-IR在4组患者间差异有统计学意义(P<0.05);总胆固醇、高密度脂蛋白与血清Irisin水平呈现明显负相关性(P<0.05);空腹胰岛素、HOM-IR、AST与血清Irisin水平呈现明显正相关性(P<0.05);多元Logistic回归分析显示HOM-IR、AST、空腹胰岛素及血清Irisin水平是影响NAFLD发生的独立危险因素(P<0.001)。[结论]血清Irisin水平是影响NAFLD发生的独立危险因素,随NAFLD病情的进展血清Irisin水平逐渐降低。
[Objective] To explore the correlation between the level of serum irisin and the severity of non-alcoholic fatty liver disease (NAFLD). [Methods] A total of 140 NAFLD patients from November 2014 to December 2015 in our hospital were selected as the research object. According to the severity of the disease, the patients were divided into mild, moderate, severe and severe disease group. Another 148 cases of healthy subjects in our hospital were selected as control group during the same period. The laboratory test data and general data were collected to analyze the correlation between Irisin level and the degree of different NAFLD lesions. [Results] The total cholesterol, triglyceride, AST, ALT, serum Irisin, systolic blood pressure, diastolic blood pressure, waist circumference, hip circumference, fasting blood glucose, fasting insulin and HOM-IR in observation group were significantly higher than those in control group (P <0.05). The levels of total cholesterol, triglyceride, serum Irisin, AST, fasting blood glucose, fasting insulin and HOM-IR in the four groups were significantly different (P <0.05) (P <0.05). Fasting insulin, HOM-IR, AST and serum Irisin levels showed a significant positive correlation (P <0.05). Multivariate logistic regression analysis showed that HOM- IR, AST, fasting insulin and serum level of Irisin were independent risk factors for the occurrence of NAFLD (P <0.001). [Conclusion] The level of serum Irisin is an independent risk factor of NAFLD. The level of serum Irisin gradually decreases with the progression of NAFLD.