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目的 探讨MMP 7在卵巢浆液性肿瘤中的表达情况。方法 采用免疫组化SP法对 6例正常卵巢、12例卵巢浆液性囊腺瘤、6例交界性囊腺瘤及 2 2例卵巢浆液性囊腺癌MMP 7的表达进行了研究。结果 正常卵巢不表达MMP 7。大部分卵巢浆液性肿瘤的胞浆及间质中都有MMP 7的阳性表达。MMP 7在卵巢良性、恶性及交界性浆液性肿瘤胞浆中的表达无明显差异 ;而在肿瘤间质中 ,恶性及交界性卵巢浆液性肿瘤中的表达远高于良性肿瘤 (P <0 .0 5 )。在交界性及恶性浆液性卵巢肿瘤中 ,部分肿瘤细胞的细胞核中也有MMP 7的表达 ,为国内外首次报道。结论 MMP 7可能在卵巢浆液性肿瘤的进展中发挥重要作用
Objective To investigate the expression of MMP-7 in ovarian serous tumors. Methods Immunohistochemical SP method was used to study the expression of MMP 7 in 6 cases of normal ovary, 12 cases of ovarian serous cystadenoma, 6 cases of borderline cystadenoma and 22 cases of ovarian serous cystadenocarcinoma. Results Normal ovary does not express MMP 7. Most ovarian serous tumors in the cytoplasm and interstitium have MMP 7 positive expression. The expression of MMP-7 in cytoplasm of ovarian benign, malignant and borderline serous tumors was not significantly different, while in malignant and borderline ovarian serous tumors, the expression of MMP-7 was significantly higher than that in benign tumors (P <0.01). 0 5). In borderline and malignant serous ovarian tumors, the expression of MMP-7 in the nuclei of some tumor cells is also reported for the first time at home and abroad. Conclusion MMP 7 may play an important role in the progress of ovarian serous tumors