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目的:研究原发性干燥综合征患者EB病毒感染的情况,了解EB病毒在干燥综合征的疾病进展中起到的作用,为该病病因研究提供依据。方法:选取干燥综合征病人26例作为实验组,健康人群30例作为对照组,通过PCR及ELISA测定两组成员EBV DNA及EBV VAC-IgA,采用SPSS 19.0进行统计学分析。结果:26例Pss患者中,23例EBV DNA阳性,阳性率88.5%;健康人群中,9例EBV DNA阳性,阳性率30%,差异具有统计学意义(P<0.01)。Pss患者组血清中EBV VAC-IgA抗体浓度显著高于对照组,差异具有统计学意义(P<0.01)。结论:EBV感染在原发性干燥综合征的发生发展中起到了重要作用。
Objective: To study the status of Epstein-Barr virus infection in patients with Sjogren’s syndrome and to understand the role of Epstein-Barr virus in the progression of Sjogren’s syndrome and to provide basis for the etiological study. Methods: Twenty-six patients with Sjogren’s syndrome were selected as experimental group and 30 healthy people as control group. EBV DNA and EBV VAC-IgA were measured by PCR and ELISA in both groups. SPSS 19.0 was used for statistical analysis. Results: Of the 26 patients with Pss, 23 had EBV DNA positive, with a positive rate of 88.5%. Among 9 healthy people, EBV DNA was positive and the positive rate was 30%. The difference was statistically significant (P <0.01). The serum levels of EBV VAC-IgA in patients with Pss were significantly higher than those in the control group (P <0.01). Conclusion: EBV infection plays an important role in the pathogenesis of Sjogren’s syndrome.