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本法采用一次提取,提取液冰冻或氮流干燥,再经硅烷化以测定马来酸麦角新碱。本法比美国药典第18版比色定量-薄层半定量(测降解物)法简便准确。层析仪装有火焰离子化鉴定器,氦为载气,固定相为涂有1%OV-1的80～100目 Gas-Chrom Q,填充于长1.2米,内经为0.64厘米的硼硅玻璃柱中。层析柱和鉴定器均应保持260℃恒温,进样注射孔温度为280℃。氦气流速为55毫升/分。
This method uses one extraction, extraction fluid freezing or nitrogen flow drying, and then silylation to determine ergonovine maleate. This method is more accurate and accurate than the 18th edition of the U.S. Pharmacopeia for quantitative colorimetric-thin semi-quantitative determination of degradation products. The chromatograph was equipped with a flame ionization detector and helium as the carrier gas. The stationary phase was 80-100 mesh Gas-Chrom Q coated with 1% OV-1, and filled in borosilicate glass with a length of 1.2 m and a inner diameter of 0.64 cm Column. Columns and detectors should be maintained at 260 ℃ constant temperature, injection injection hole temperature of 280 ℃. The helium flow rate was 55 ml / min.