论文部分内容阅读
本文介绍间接标记(添加螯合剂酒石酸)~(99m)Tc-HSA药盒的方法。药盒质量难以控制。对二氯化锡储存液中Sn~(2+)进行滴定;选择化学分析法并综合评价标记效果;以正交法实验选取最佳标记条件;通过比较,确定药盒配方:HSA 7mg、酒石酸 1.08mg、SnCl_2·2H_2O 0.16mg、pH3.5;五批冻干药盒鉴定:标记率>95％,血液清除率-0.0026(平均斜率),药盒有效储存期6个月;本药盒与核素听诊器配合,测定心脏功能,获得良好效果。
This article describes a method of indirect labeling (adding chelator tartrate) ~ (99m) Tc-HSA kit. The quality of the kit is hard to control. Titration of Sn2 + in the stock solution of tin dichloride was carried out. The chemical analysis method was used to evaluate the labeling effect comprehensively. The optimal labeling conditions were selected by the orthogonal test. The formulation of the kit was determined by HSA 7 mg, tartaric acid 1.08mg, SnCl_2 · 2H_2O 0.16mg, pH3.5; five batch freeze-dried kit identification: labeling rate> 95%, blood clearance -0.0026 (average slope), the effective storage period of 6 months; Radionuclide with the determination of cardiac function, get good results.