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AIM:To evaluate the use of the trypsinogen-2 dipstick (Actim Pancreatitis) test for early diagnosis and prediction of severity in acute pancreatitis (AP). METHODS:Ninety-two patients with AP were included in this study.The control group was 25 patients who had acute abdominal pain from non-pancreatic causes.Urine trypsinogen-2 dipstick test (UTDT) and conventional diagnostic tests were performed in all patients.Patients were divided by the Atlanta classification into two groups as having mild or severe pancreatitis. RESULTS:UTDT was positive in 87 (94.6%) of the AP patients and in two (8%) controls (P<0.05).Positive UTDT was found in 61 (92.4%) of 66 (71.7%) patients with mild pancreatitis and in all (100%) of the 26 (28.3%) with severe pancreatitis (P>0.05).UTDT positivity lasted longer in severe pancreatitis compared with that in mild pancreatitis (6.2±2.5 d vs 2.0±1.43 d,P<0.05). The sensitivity,specificity,positive predictive value, negative predictive value (NPV),positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of UTDT were 91%,72%,96.6%,70.4%,3.4 and 0.1,respectively. CONCLUSION:UTDT is a simple,rapid and reliable method for use on admission.It has high specificity and low NLR for early diagnosis and prediction of severity in AP.However,its relatively low NPV does not allow trypsinogen-2 dipstick test to be a stand-alone tool for diagnosis of acute pancreatitis;the use of other conventional diagnostic tools remains a requirement.
AIM: To evaluate the use of the trypsinogen-2 dipstick (Actim Pancreatitis) test for early diagnosis and prediction of severity in an acute pancreatitis (AP). METHODS: Ninety-two patients with AP were included in this study. Control group was 25 patients who had acute abdominal pain from non-pancreatic causes. Urine trypsinogen-2 dipstick test (UTDT) and conventional diagnostic tests were performed in all patients. Patients were divided by the Atlanta classification into two groups as having mild or severe pancreatitis. RESULTS: UTDT was found to be positive in 87 (94.6%) of the AP patients and in two (8%) controls (P <0.05). Positive UTDT was found in 61 (92.4%) of 66 (100%) of the 26 (28.3%) with severe pancreatitis (P> 0.05) .UTDT positivity lasted longer in severe pancreatitis compared with that in mild pancreatitis (6.2 ± 2.5 days vs. 2.0 ± 1.43 days, P <0.05) sensitivity, specificity, positive predictive value, negative predictive value (NPV), positive likeli CONCLUSION: The UTDT is a simple, rapid and reliable method for use on admission. It has been demonstrated that UTDT was 91%, 72%, 96.6%, 70.4%, 3.4 and 0.1, respectively. has high specificity and low NLR for early diagnosis and prediction of severity in AP. Yet, its relatively low NPV does not allow trypsinogen-2 dipstick test to be a stand-alone tool for diagnosis of acute pancreatitis; the use of other conventional diagnostic tools remains a requirement.