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不同剂量的ＮｉＣｌ＿２（０．４、０．８、１．６、３．２、６．４ｍｍｏｌ／Ｌ）均能降低人离体子宫肌条的自发收缩强度、张力和曲线下面积（ＵＣＡ），随浓度增加抑制作用加强。ＩＣ＿（５０）为１．６４±０．６５ｍｍｏｌ／Ｌ，但对自发收缩频率无显著抑制作用。ＮｉＣｌ＿２能显著抑制Ｃａ￣（２＋）引起的子宫收缩。半数抑制浓度的ＮｉＣｌ＿２显著抑制了催产素引起的依细胞内Ｃａ￣（２＋）的收缩反应，而对依细胞外Ｃａ￣（２＋）的收缩反应无显著影响。
Different doses of NiCl_2 (0.4,0.8,1.6,3.2,6.4mmol / L) can reduce the spontaneous contractility, tension and area under the curve (UCA) of isolated human uterine muscle strips, With the concentration increased inhibitory effect. IC 50 (50) was 1.64 ± 0.65mmol / L, but no significant inhibition of spontaneous contraction frequency. NiCl_2 can significantly inhibit the Ca ~ (2+) induced uterine contraction. NiCl 2 at half maximal inhibitory concentration significantly inhibited oxytocin-induced contractile response of intracellular Ca 2+, but had no significant effect on extracellular Ca 2+ contraction.