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目的探讨Fe3O4热疗对小鼠S180腹腔积液肿瘤的作用。方法建立小鼠S180腹腔积液瘤模型,分为对照组(Ⅰ组)、单纯注射Fe3O4组(Ⅱ组)及注射Fe3O4并进行热疗组(Ⅲ组),通过处理后各组小鼠腹围、腹腔积液量、体重、生存期及肿瘤细胞死亡率的比较,观察Fe3O4热疗对于S180的作用。结果腹围测量的结果显示腹腔Ⅲ组小鼠腹围明显小于Ⅰ组及Ⅱ组,存活天数表明,Ⅲ组小鼠存活时间长于其他二组;Ⅲ组小鼠死亡时腹腔积液量明显低于其他二组;肿瘤细胞死亡率结果显示,Ⅲ组对比其他二组肿瘤细胞死亡率明显增高。结论Fe3O4热疗对于小鼠S180腹腔积液肿瘤有一定的治疗作用。
Objective To investigate the effect of Fe3O4 hyperthermia on S180 ascites tumor in mice. Methods The model of S180 peritoneal hydrops in mice was established and divided into control group (group Ⅰ), Fe3O4 group (group Ⅱ), Fe3O4 group and hyperthermia group (group Ⅲ) , Peritoneal effusion volume, body weight, survival and tumor cell death rate compared to observe the effect of Fe3O4 hyperthermia on S180. Results The results of abdominal circumference measurement showed that the abdominal circumference of group Ⅲ was significantly less than that of group Ⅰ and group Ⅱ, and the number of surviving days showed that the survival time of group Ⅲ was longer than that of the other two groups. The number of peritoneal effusion of group Ⅲ was significantly lower than that of group Ⅲ The other two groups; tumor cell mortality results showed that the other three groups compared with the other two groups of tumor cell mortality was significantly higher. Conclusion Fe3O4 hyperthermia has a certain therapeutic effect on mice S180 peritoneal effusion.