1967年报导,口服新霉素每天0.5～2.0克,12个月以上的16例患者平均总胆固醇的下降约15～32％。有人对一组患者观察了1～2.5年,用药后胆固醇下降22％,继续用药时效果仍存在,在大便中见胆固醇和胆酸排泄增加。新霉素降血脂作用机理主要是减少肠内胆酸的吸收,这可能是通过(1)肠内细菌能将胆酸转化为二 1967 reported that oral neomycin 0.5 to 2.0 grams per day, 16 patients over 12 months the average total cholesterol dropped about 15 to 32%. Someone observed a group of 1 to 2.5 years, after treatment, cholesterol decreased by 22%, the effect is still there when the drug continues to use, in the stool to see the increase in cholesterol and bile acid excretion. Neomycin hypolipidemic mechanism of action is mainly to reduce the absorption of intestinal bile acids, which may be through (1) intestinal bacteria can be converted to bile acid