论文部分内容阅读
应用电生理技术研究了苦皮藤素 对兴奋性突触后电位 ( EPSP)和神经 -肌肉接头兴奋性接点电位 ( EJPs)的作用。甘露醇间隙法对美洲大蠊 ( Periplaneta americana)中枢神经离体标本兴奋性突触后电位 ( EPSP)的测定表明 ,质量浓度为 0 .1 g/L的苦皮藤素 在用药后 72 min阻断了 EPSP。细胞内微电极记录法对果蝇 ( Drosophila melanogaster)运动神经 ,即腹纵肌离体标本的神经 -肌肉兴奋性接点电位 ( EJPs)的测定表明 ,0 .1 g/L的苦皮藤素 作用 1 9.5min可阻断 EJPs。
The effects of celangulin on excitatory postsynaptic potential (EPSP) and neuromuscular junction excitability potential (EJPs) were studied using electrophysiological techniques. Mannitol clearance assay of excitatory postsynaptic potential (EPSP) in Periplaneta americana central nervous system specimens showed that cephalosporin at a concentration of 0.1 g / L was blocked at 72 min Off EPSP. Measurement of neuromuscular excitatory junction potentials (EJPs) in isolated Drosophila melanogaster motor nerve, ie, abdominoplasty muscle, by intracellular microelectrode recording showed that celangulin at 0.1 g / L 1 9.5min can block EJPs.