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目的:观察中西医结合治疗对缺血性脑卒中患者血管内皮功能的影响。方法:将76例缺血性脑卒中患者随机分为西医组与中西医组各38例。西医组给予常规西药治疗,中西医组在西医组治疗基础上加用益气活血通络汤口服。观察2组治疗前后血管性假血友病因子(v WF)、血管内皮细胞钙黏蛋白(VE-cadherin)水平以及脑梗死病灶大小的变化。结果:治疗后,2组v WF、VE-cadherin水平以及脑梗死病灶大小均较治疗前下降或缩小(P<0.01),中西医组3项指标的下降或缩小幅度均大于西医组(P<0.05)。结论:与单纯西医治疗相比,中西医结合治疗气虚血瘀型缺血性脑卒中患者的疗效更佳,能有效降低血清v WF和VE-cadherin水平,保护与修复受损的血管内皮功能,增加易损动脉斑块的稳定性,从而缩小脑梗死病灶。
Objective: To observe the effect of integrated traditional Chinese and western medicine on vascular endothelial function in patients with ischemic stroke. Methods: 76 cases of ischemic stroke were randomly divided into western medicine group and western medicine group of 38 cases. Western medicine group to give conventional Western medicine, Western medicine group in the Western medicine group based on the treatment with Yiqi Huoxue Tongluo Tang oral. The changes of vWF, VE-cadherin and infarct size in two groups before and after treatment were observed. Results: After treatment, the levels of vWF and VE-cadherin in both groups and the size of cerebral infarction lesion decreased or decreased compared with that before treatment (P <0.01). The three indexes of Chinese and Western medicine groups decreased or shrank more than western medicine group (P < 0.05). Conclusion: Compared with western medicine alone, the combination of traditional Chinese and western medicine is more effective in treating ischemic stroke with qi deficiency and blood stasis type, which can effectively reduce the levels of vWF and vE-cadherin, protect and repair the damaged vascular endothelial function, Increase the stability of vulnerable plaque, thereby reducing the infarction lesions.