结核病的化学治疗过程中不可避免会出现肝功能损害(药物性肝损害,DILI),其发生概率大约8%[1]。本资料收集我院2000年1月~2008年12月肺结核及结核性胸膜炎患者1048例,抗结核治疗过程中出现药物性肝损害72例,发生率6.87%;现回顾分析探讨药物性肝损害的发生机制、危险因素和发生时 It is inevitable that liver damage (drug-induced liver damage, DILI) can occur during chemotherapy in tuberculosis, with a probability of about 8% [1]. The data collected in our hospital from January 2000 to December 2008 1048 cases of tuberculosis and tuberculous pleurisy, anti-TB treatment in the process of drug-induced liver damage in 72 cases, the incidence rate of 6.87%; now revisited to explore the drug-induced liver damage Mechanism of occurrence, risk factors and when they occur