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实验和流行病学的研究已表明六价铬化合物是主要的致癌物和诱变物,而三价铬通常无活性,可能是其很少能透过生物膜的结果。然而,在进入细胞以后,六价铬迅速还原成三价铬,后者可能是细胞内仅有的形式,最终致毒剂。本文报告了两种六价铬盐(K_2Cr_2O_7,CaCrO_4)对培养中胚胎发育的毒作用,并和三价铬盐(Cr(NO_3)_3)的毒作用进行了比较。
Experimental and epidemiological studies have shown that hexavalent chromium compounds are the major carcinogens and mutagens, while trivalent chromium is generally inactive and may be the result of its low ability to penetrate biofilms. However, upon entry into the cell, hexavalent chromium is rapidly reduced to trivalent chromium, which may be the only intracellular form, eventually the toxicant. In this paper, the toxic effects of two hexavalent chromium salts (K 2 Cr 7 O 7, CaCrO 4) on embryo development in culture were reported and compared with those of Cr (NO 3) 3.