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目的 分析成都市郫县2011-2015年疑似预防接种异常反应(AEFI)的发生特征.方法 通过AEFI信息管理系统,收集整理郫县2011-2015年报告的AEFI个案数据,采用描述流行病学的方法对监测数据进行统计分析.结果 郫县2011-2015年共报告AEFI病例357例,报告发生率为19.82/10万.其中一般反应282例(78.99％),异常反应71例(19.89％),偶合症4例(1.12％),无疫苗质量事故、接种事故和心因性反应;报告单位覆盖率(100％)、48 h内报告率(98.32％)、48 h内调查率(100％)、3d内调查表报告率(93.33％)、个案调查表关键项目完整率(100％)、分类率(100％),均达到国家监测方案要求;男女性别比为1.33∶1,并主要集中在1岁以下儿童;发生月份主要集中在4～9月,其中9月份报告例数最多;一类疫苗AEFI报告发生率高于二类疫苗,AEFI报告病例发生时间主要集中在ld以内,且临床症状主要是一过性、轻微的一般反应.结论 近年来,郫县无疫苗质量事故、接种事故发生,预防接种操作和疫苗总体安全性较好.1岁及以下年龄组儿童、一类疫苗、以及夏秋季报告病例数较多,建议重点加强监测.“,”Objective To explore the features of adverse events following immunization (AEFI) in Pixian of Chengdu from 2011 to 2015.Methods The AEFI data were collected from the national AEFI information system 2011 to 2015 for descriptive analysis.Results There were 357 AEFI cases were reported in from 2011 to 2015 which was average incidence was 19.82/105.The general reaction was 282 cases (78.99％);the abnormal reaction was 71 cases (19.89％);the coupling reaction was 4 cases (1.12％);and no vaccine quality accident,failure of vaccine inoculation and psychogenic reaction.The coverage rate of reporting was 100％;the timely report rate within 48 hours was 98.32％;the investigation rate within 48 hours was 100％;the questionnaire-reporting rate within 3 days was 93.33％;the questionnaire-completion rate was 93.33％;questionnaire-classification rate was 100％.All indicators of monitoring have reached the requirements of the national standards.The ratio of male to female was 1.33∶ 1,which mainly concentrated in children under 1 years of age.The cases concentrated in April to September,which the most number of cases reported in September.The incidence of first class of vaccine AEFI was higher than that of the second class.The time of AEFI report was mainly concentrated within 1 day,and the main clinical symptoms were transient and mild general response.Conclusion In recent years,the vaccine operation and safety have been improved for no vaccine quality accident and failure of vaccine inoculation.It should be strengthened monitoring for the children less than 1 years age,first class of vaccines and cases in summer and autumn.