1型糖尿病患者在接受胰岛素及其他降糖药物治疗时,低血糖是常见且严重的并发症。不同于非糖尿病人群,长病程的糖尿病患者往往不能通过神经和体液调节来维持机体血糖水平的稳定,同时也不能感知低血糖的发生,从而导致血糖进一步降低,引发低血糖脑损伤。而近期的相关研究揭示,上述现象的存在和糖尿病患者在发生低血糖时脑组织的代谢方式改变有密切联系。 Hypoglycemia is a common and serious complication when patients with type 1 diabetes receive insulin and other hypoglycemic agents. Different from non-diabetic patients, patients with long-term diabetes often can not maintain the stability of blood sugar level through nerve and body fluid regulation, and can not perceive the occurrence of hypoglycemia at the same time, resulting in further lowering of blood glucose and triggering hypoglycemic brain injury. Recent studies have revealed that the existence of these phenomena is closely related to changes in the metabolic pattern of brain tissue in patients with diabetes when hypoglycemia occurs.