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目的:研究益心通络颗粒对大鼠急性心肌缺血和血液流变学的影响。方法:采用大鼠冠脉结扎致急性心肌缺血模型考察受试药物抗心肌缺血作用;采用肾上腺素-冰水浴导致急性血瘀模型,考察益心通络颗粒对血流变的影响。结果:益心通络颗粒可明显减少梗死面积和降低血清CK、LDH活力和MDA含量,升高SOD活力,改善心肌缺血大鼠心电图J点抬高和血流动力学异常,降低血瘀大鼠ηp和HCT。结论:益心通络颗粒对冠脉结扎所致急性心肌缺血有一定保护作用,并能改善血液流变性。
Objective: To study the effect of Yixintongluo Granule on acute myocardial ischemia and hemorheology in rats. Methods: The model of acute myocardial ischemia induced by coronary ligation in rats was used to investigate the anti-ischemic effect of the tested drugs. The model of acute blood stasis was induced by adrenaline-ice water bath to study the influence of Yixintongluo Granules on the hemorrheology. Results: Yixintongluo Granule can obviously reduce infarction area, decrease serum CK, LDH activity and MDA content, increase SOD activity, improve electrocardiogram J point elevation and hemodynamics in myocardial ischemia, and reduce blood stasis Mouse ηp and HCT. Conclusion: Yixintongluo Granule has a protective effect on acute myocardial ischemia induced by coronary artery ligation, and can improve hemorheology.