论文部分内容阅读
AIM:To investigate the effect of repeated lower +Gzexposure on liver injury induced by high +Gz exposure in rats.METHODS:Sixty male Wister rats were randomly divided into a blank control group,a low G preconditioning group(LG)(exposed to +4 Gz/5 min per day for 3 d before +10 Gz/5 min exposure),and a +10 Gz/5 min group(10G)(n = 20 in each group).Blood specimens and liver tissue were harvested at 0 h and 6 h after +10 Gz/5 min exposure.Liver function was analyzed by measuring serum alanine transaminase(ALT) and aspartate aminotransferase(AST) levels,and liver injury was further assessed by histopathological observation.Malondialdehyde(MDA),superoxide dismutase(SOD) and Na+-K+-ATPase were determined in hepatic tissue.RESULTS:The group LG had lower ALT,AST,and MDA values at 0 h after exposure than those in group 10 G.SOD values and Na+-K+-ATPase activity in the LG group were higher than in group 10 G 0 h post-exposure.Hepatocyte injury was significantly less in group LG than in group 10 G on histopathological evaluation.CONCLUSION:It is suggested that repeated low +Gz exposure shows a protective effect on liver injury induced by high +Gz exposure in rats.
AIM: To investigate the effect of repeated lower + Gzexposure on liver injury induced by high + Gz exposure in rats. METHODS: Sixty male Wister rats were randomly divided into a blank control group, a low G preconditioning group (LG) (exposed to + 4 Gz / 5 min per day for 3 d before +10 Gz / 5 min exposure), and a +10 Gz / 5 min group (10G) (n = 20 in each group). Blood specimens and liver tissue were harvested at 0 h and 6 h after +10 Gz / 5 min exposure. Liver function was analyzed by measuring serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and liver injury was further assessed by histopathological observation. Malondialdehyde (MDA), superoxide dismutase (SOD) and Na + -K + -ATPase were determined in hepatic tissue .RESULTS: The group LG had lower ALT, AST, and MDA values at 0 h after exposure than those in group 10 G.SOD values and Na + -K + -ATPase activity in the LG group were higher than in group 10 G 0 h post-exposure. Hepatatocyte injury was significantly less in group LG than in group 10 G on histopathological evaluation. CONCLUSION: It is suggested that that repeated low + Gz exposure shows a protective effect on liver injury induced by high + Gz exposure in rats.