多发性骨髓瘤 (multiplemyeloma,MM)是一种浆细胞恶性增殖性疾病 ,由于瘤细胞的增殖比例很低及多药耐药的形成 ,MM的临床治疗仍然十分困难 ,迄今为止仍无根治的方法。近年来对MM的治疗有一些新的进展 ,本文就此问题作一综述。1　化学治疗自 2 0世纪 60年代应用马法兰和泼尼松 ( Multiple myeloma (MM) is a malignant proliferative plasma cell disease. Due to the low proliferation rate of multi-drug-resistant tumor cells and the formation of multidrug resistance, the clinical treatment of MM is still very difficult, so far there is no radical method . In recent years, some new advances have been made in the treatment of MM. This article reviews the issue. 1 chemotherapy since the 20th century 60’s application of melphalan and prednisone (