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目的:探讨重复经颅磁刺激联合生物反馈用于帕金森病非运动症状的临床疗效及对血清IL-6,CRP及TNF-α水平的影响。方法:收集我院就诊的84例帕金森病患者,随机分为实验组和对照组,每组42例。对照组患者给予肌电、脑电生物反馈治疗,实验组患者在对照组基础上给予重复经颅磁刺激治疗。观察并比较两组患者治疗前后血清C反应蛋白(CRP)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平以及非运动症状筛查问卷(NMSQuest)、帕金森病睡眠量表(PDSS)、汉密尔顿抑郁量表(HAMD)评分的变化情况。结果:与治疗前相比,治疗后患者CRP,IL-6及TNF-α水平以及NMSQuest、HAMD评分均下降,而PDSS评分均升高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者血清CRP,IL-6及TNF-α水平以及NMSQuest、HAMD评分较低,而PDSS评分较高,差异具有统计学意义(P<0.05)。结论:重复经颅磁刺激联合生物反馈能够降低帕金森病患者血清IL-6、CRP、TNF-α水平且对于非运动症状的临床疗效较好。
Objective: To investigate the clinical effects of repeated transcranial magnetic stimulation combined with biofeedback on non-motor symptoms of Parkinson’s disease and its effect on serum IL-6, CRP and TNF-α levels. Methods: Eighty-four patients with Parkinson’s disease who were treated in our hospital were randomly divided into experimental group and control group, 42 cases in each group. Patients in the control group were treated with electromyography and electroencephalogram biofeedback. Patients in the experimental group were treated with repeated transcranial magnetic stimulation on the basis of the control group. The levels of serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and NMSQuest before and after treatment were compared between the two groups. Sleep scale (PDSS), Hamilton Depression Scale (HAMD) score changes. Results: The levels of CRP, IL-6, TNF-α, NMSQuest and HAMD in patients after treatment were significantly lower than those before treatment, while the PDSS scores were significantly higher than those before treatment (P <0.05) Compared with the experimental group, serum CRP, IL-6 and TNF-α levels and NMSQuest, HAMD score lower, while PDSS score higher, the difference was statistically significant (P <0.05). CONCLUSION: Repeated transcranial magnetic stimulation combined with biofeedback can reduce the levels of serum IL-6, CRP and TNF-α in patients with Parkinson’s disease and has good clinical efficacy for non-motor symptoms.