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CD4~+T细胞是HIV-1感染的主要靶细胞。HIV-1感染导致CD4~+T细胞数量减少,宿主免疫功能缺陷,是艾滋病的主要发病机制。大量的研究发现,HIV-1感染可通过多种机制导致CD4~+T细胞的死亡。本文讨论有关HIV-1感染导致CD4~+T细胞死亡机制的研究新进展,重点描述HIV-1基因整合诱导CD4~+T细胞凋亡和顿挫型HIV-1感染导致CD4~+T细胞焦亡及其相关机制。认识和了解CD4~+T细胞死亡机制,将有助于预防和治疗HIV-1感染。
CD4 ~ + T cells are the major target cells for HIV-1 infection. HIV-1 infection leads to a decrease in the number of CD4 ~ + T cells, host immune function defects, is the main pathogenesis of AIDS. Numerous studies have found that HIV-1 infection can lead to the death of CD4 ~ + T cells through a variety of mechanisms. This article discusses the new progress on the mechanism of CD4 ~ + T cell death induced by HIV-1 infection. It focuses on the induction of CD4 ~ + T cell apoptosis by HIV-1 gene integration and the focal apoptosis of CD4 ~ + T cells by flipping HIV-1 infection And its related mechanisms. Understanding and understanding of CD4 ~ + T cell death mechanism will help prevent and treat HIV-1 infection.