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HDV的存在可使慢性HBV感染者的病情加重,且预后也较无合并感染者差,罕见自然缓解。皮质激素类或其它免疫抑制剂治疗对这类病人无效,迄今抗病毒治疗经验也很有限。小样本试验证明α-干扰素(α-IFN)治疗与HDV RNA减少及AST降低有关,但均为短疗程且效果短暂。本文作者通过随机对照研究以确定使用已知对慢性HBV感染治疗有效的α-IFN剂量,以长疗程(12个月)是否能稳定缓解HDV感染及
The presence of HDV can exacerbate the condition of patients with chronic HBV infection, and the prognosis is also worse than that without infection, a rare natural remission. Corticosteroids or other immunosuppressive agents are ineffective in these patients and so far experience with antiviral therapy has been limited. Small sample trials demonstrate that alpha-interferon (IFN-α) therapy is associated with reduced HDV RNA and decreased AST, both in short courses and with short-term effects. The authors randomized controlled trials to determine if a long course of treatment (12 months) would stabilize HDV infection using a dose of alpha-IFN that is known to be effective in treating chronic HBV infection and