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目的分析非酒精性脂肪性肝炎(NASH)组织Kupffer细胞中Lyn酶的表达及其临床意义。方法收集37例手术切除的肝组织石蜡标本,其中12例原发性肝癌癌旁正常肝组织,25例炎症反应明显的NASH组织。利用免疫组化法检测肝组织Kupffer细胞中Lyn酶的表达情况,并分析其阳性率与肝组织炎症的相关性。结果 25例NASH患者Lyn酶阳性表达25例,其中染色强度以上的23例(92%),Lyn阳性率与NASH的炎症程度呈正相关(P<0.05)。结论 Lyn的异常表达与肝脏炎症程度显著相关,检测其表达有助于NASH炎症程度的评价。
Objective To analyze the expression of Lyn enzyme in Kupffer cells of non-alcoholic steatohepatitis (NASH) and its clinical significance. Methods Seventy - seven paraffin - embedded specimens of liver tissue were collected, including 12 normal liver tissues adjacent to the primary liver cancer tissues and 25 NASH tissues with obvious inflammatory response. Immunohistochemistry was used to detect the expression of Lyn enzyme in Kupffer cells, and the relationship between the positive rate and hepatic inflammation was analyzed. Results Twenty-five cases of NASH were positive for Lyn. The positive rate of Lyn was 23 (92%) and the positive rate of Lyn was positively correlated with the degree of inflammation of NASH (P <0.05). Conclusion The abnormal expression of Lyn is significantly correlated with the degree of liver inflammation. To detect the expression of Lyn is helpful to evaluate the degree of inflammation in NASH.