论文部分内容阅读
为了给组织液的透皮抽取提供负压值,本文研究了结构简单、加工方便的PDMS微型文氏管的优化设计.首先理论推导了文氏管的结构参数对输出负压的影响规律,然后采用Fluent进行模拟计算,接着用模塑法设计加工了PDMS文氏管,并搭建了文氏管输出负压的检测系统,最后对实验结果进行分析讨论.通过对比测量,给出了适用于本文的微型化文氏管结构,即喉管长×宽×高为6 mm×0.25 mm×0.25 mm、收缩角30°、扩散角30°.本文设计加工的文氏管在220 kPa的正压下可输出87 kPa的负压,提高了组织液透皮抽取的效率.该微型文氏管同以往的真空发生装置相比既能满足系统小型化和集成化要求,又能在相对较小的输入压强下,为组织液透皮抽取提供足够高的真空负压输出,为驱动微管路内流体输运提供足够大的抽取速率.
In order to provide negative pressure value for transdermal extraction of tissue fluid, the optimal design of PDMS micro-venturi with simple structure and convenient processing is studied in this paper.Firstly, the influence of structural parameters of Venturi tube on negative pressure of output is derived theoretically, Fluent was used to simulate and calculate PDMS venturi tube by molding method, and a detection system of venturi negative pressure was set up.Finally, the experimental results were analyzed and discussed.According to the contrast measurement, Miniature venturi structure, that is, the length of the throat × width × height of 6 mm × 0.25 mm × 0.25 mm, the contraction angle of 30 °, the diffusion angle of 30 ° .This paper designed and processed Venturi at 220 kPa positive pressure The output of 87 kPa negative pressure to improve the efficiency of transdermal tissue fluid extraction.The micro-venturi compared with the previous vacuum generation device to meet both system miniaturization and integration requirements, but also at a relatively low input pressure , Provides a sufficiently high vacuum negative pressure output for tissue fluid percutaneous extraction and provides a sufficiently large extraction rate for driving fluid transport within the microchannels.