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［３Ｈ］谷氨酸（Ｃｌｕ）ｓｃ后的不同时程，柱层析分离血清中［３Ｈ］Ｇｌｕ，液闪测定，发现随代谢时程的延长［３Ｈ］Ｇｌｕ的量明显降低。外周组织中［３Ｈ］Ｇｌｕ含量的变化与血清中的类似，而神经组织则不同。非标记谷氨酸单钠ｓｃ以剂量依赖方式损伤成年小鼠的分辨学习能力。引起特征性神经元退变，降低下丘脑和脊髓的线粒体膜结合钙水平。结果表明，４．０ｍｇ·ｇ－１谷氨酸单钠可以透过血脑屏障对成年动物产生神经毒性作用。其作用机理可能与细胞内Ｃａ２＋超载，线粒体封存或排空Ｃａ２＋的能力失常。最终导致神经元损伤甚至死亡有关。
[3H] glutamate (Clu) sc after different time, column chromatography [3H] Glu serum, liquid flashed determination and found that with the prolonged metabolic duration [3H] Glu significantly decreased. Changes in the content of [3H] Glu in peripheral tissues were similar to those in serum, but the neural tissues were different. Unlabeled monosodium glutamate sc scans the learning ability of adult mice in a dose-dependent manner. Causing degeneration of characteristic neurons, reducing mitochondrial membrane bound calcium levels in the hypothalamus and spinal cord. The results showed that monosodium glutamate 4.0mg · g-1 can have neurotoxic effects on adult animals through the blood-brain barrier. Its mechanism of action may be related to intracellular Ca2 + overload, mitochondrial sequestration or the ability to empty Ca2 +. Eventually leading to neuronal damage or even death.