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为预防和治疗呼吸器官感染性和变态反应性疾病,探讨免疫的局部调节,作者用最有效的免疫调节剂——左旋咪唑和免疫抑制剂——硫唑嘌呤对小鼠呼吸器官的局部和全身免疫的调节特点进行了试验研究。试验选用64只体重为17～20克的CBA小鼠。试验组32只气管内注入0.3ml含6mg硫唑嘌呤的生理盐水,对照组32只注入0.3ml单纯生理盐水。一天后,两组各选16只连续吸入左旋咪唑4天(微粒直径为15μm的雾化剂100μg)。第5天将只给硫唑嘌呤的8只,给硫唑嘌呤并吸入左旋咪唑的8只和对照组16只小鼠,气管内注入1ml中含1×10~(10)羊红细胞之0.9%氯化钠液0.3ml进行免疫。将另外8只给硫唑嘌呤并吸入
To prevent and treat respiratory infections and allergic diseases, to explore the local immune regulation, the author with the most effective immunomodulator - levamisole and immunosuppressive agents - azathioprine on the respiratory organs of mice and local and systemic Immune regulation characteristics of the experimental study. Sixty-four CBA mice weighing 17-20 g were used in the experiment. In the experimental group, only 0.3 ml of saline containing 6 mg of azathioprine was injected into the trachea and 32 of the control group into 0.3 ml of saline. One day later, 16 animals in each of the two groups were continuously inhaled levamisole for 4 days (100 μg aerosolized agent having a particle diameter of 15 μm). On day 5, only 8 of azathioprine, 8 of azathioprine and inhaled levamisole and 16 mice of control group were given intratracheal intratracheal injection of 0.9% fetal bovine serum containing 1 × 10 ~ (10) 0.3ml sodium chloride solution for immunization. Add another 8 to azathioprine and inhale