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为了减小双氯灭痛对胃肠道刺激，减少服药次数，开发新的给药剂型，本研究分别以Ⅱ号丙烯酸树脂和Ⅳ号丙烯酸树脂为包衣材料，将其制成肠溶型级释微丸。体外溶出测定结果表明，该肠溶型缓释微丸在以人工胃液为溶出介质中，12h内无药物释放；在以人工肠液为溶出介质中，12h内最大释药百分率为84．5％，释药75％的时间为6h，达到缓释效果。
In order to reduce the gastrointestinal stimulation of diclofenac and reduce the number of administration, and to develop new dosage forms, this study, respectively, No. II acrylic resin and No. IV acrylic resin coating material, made of enteric coated grade pellets . In vitro dissolution results showed that the enteric-coated sustained-release pellets in the artificial gastric juice as the dissolution medium, no drug release within 12h; artificial intestinal juice as the dissolution medium, the maximum release rate within 12h was 84.5% Release 75% of the time for 6h, to slow release effect.