混旋氯霉素的棕榈酸酯在制造片剂时,如按一般比例配加崩解剂等辅料进行生产,其所制得的片剂往往长达数日亦不崩解。为解决此问题,有些药厂采用增加辅料的办法来确保产品的崩解时间符合药典的规定。所加辅料以淀粉为主,其量达主药的2.5—6倍。但是,制得的片形过大,远不符合医疗临床用药的要求,而且也增加了生产成本。 Chloramphenicol mixed palmitate in the manufacture of tablets, such as the general proportion of disintegrants with additional ingredients such as production, the tablets produced often for up to several days does not disintegrate. In order to solve this problem, some pharmaceutical companies use excipients to ensure that the disintegration time of the products meets the requirements of the Pharmacopoeia. The added materials to starch, the amount of main drug 2.5-6 times. However, the resulting sheet is too large, far from meeting the requirements of medical clinical use, but also increased production costs.