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目的探讨人乳头状瘤病毒(HPV)检测在宫颈非典型鳞状上皮细胞(ASC)分流管理中的作用。方法收集2014年11月-2016年2月南京市江宁区妇幼保健所进行宫颈癌筛查的2 553例妇女资料,对薄层液基细胞学(TCT)检测为ASC的214例妇女进行HPV检测,按检测结果分为HPV阳性组和阴性组;HPV16/18阳性组和其他亚型组。结果 214例ASC妇女中HPV阳性占49.53%(106/214),HPV16/18阳性29例;HPV阳性组中组织病理学阳性率47.17%(50/106),HPV阴性组阳性率0.93%(1/108),两组病理阳性率比较,差异有统计学意义(P<0.05);HPV16/18阳性组病理诊断CINⅠ、CINⅡ及以上分别为17.24%(5/29)、68.97%(20/29),其他亚型组28.57%(22/77)、3.90%(3/77),两组CINⅠ比较,差异无统计学意义(P>0.05),CINⅡ及以上发生率比较,差异有统计学意义(P<0.05)。结论应重视ASC妇女的HPV检测,HPV16/18阳性者应引起注意;HPV检测是基层妇保所分流管理ASC的合理方法。
Objective To investigate the role of human papillomavirus (HPV) in the management of atypical squamous cell carcinoma (ASC). Methods The data of 2 553 women who underwent cervical cancer screening from November 2014 to February 2016 in Jiangning District MCH in Nanjing were collected and HPV was detected in 214 women with ASC detected by TLCT. According to the test results were divided into HPV positive group and negative group; HPV16 / 18 positive group and other subtypes. Results The HPV positive rate was 49.53% (106/214) and HPV16 / 18 was positive in 214 ASC patients. The positive rate of HPV in the HPV positive group was 47.17% (50/106) and the positive rate in HPV negative group was 0.93% (1 / 108). There was a significant difference between the two groups (P <0.05). The positive rates of CINⅠ and CINⅡ in the HPV16 / 18 positive group were 17.24% (5/29) and 68.97% (20/29) ), Other subtypes 28.57% (22/77) and 3.90% (3/77). There was no significant difference in CINⅠ between the two subgroups (P> 0.05). The difference between the two groups was statistically significant (P <0.05). Conclusions Should pay attention to the HPV detection of ASC women, HPV16 / 18 positive should pay attention; HPV testing is a reasonable method of diversion of ASC for primary care.