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对４０例慢性阻塞性肺病（ＣＯＰＤ）患者进行氨茶碱药物动力学测定。结果显示：慢性喘息支气管炎（喘支）消除速率常数Ｋ０．０９３４±０．０１４（ｈ－１），消除半衰期Ｔ１／２７．６±１．３；肺心病伴肺部感染或呼吸衰竭Ｋ０．０６５±０．０２（ｈ－１），Ｔ１／２１２．０±３．９（ｈ）；肺心病伴心、肝功能异常者Ｋ０．０３８±０．０１６（ｈ－１），Ｔ１／２２１．５±９．５（ｈ）。本文比较了３种给药方法的血药浓度并探讨适合我国老年ＣＯＰＤ患者的氨茶碱剂量
Aminophylline pharmacokinetics was determined in 40 patients with chronic obstructive pulmonary disease (COPD). The results showed that the elimination rate constant of chronic asthmatic bronchitis (KO) was K0.0934 ± 0.014 (h-1), and the elimination half-life was T1 / 27.6 ± 1.3. Pulmonary heart disease with pulmonary infection or respiratory failure K0. 065 ± 0.02 (h-1), T1 / 212.0 ± 3.9 (h); K0.038 ± 0.016 (h-1), T1 / 221 in patients with pulmonary heart disease with heart and liver dysfunction. 5 ± 9.5 (h). This article compares the plasma concentrations of three administration methods and discusses the aminophylline dose suitable for elderly COPD patients in our country