血小板激活因子(PAF)是活性很强的脂质介质,静脉注射可引起动物体循环动脉压降低、心肌收缩功能抑制和血管壁通透性升高。本研究应用激光多普勒微循环显微镜技术,观察了PAF对大鼠活体肠系膜微循环的影响。结果发现,静脉注射PAF可引起体循环平均动脉压下降,肠系膜细动脉和细静脉血流速度减慢,血管口径 Platelet-activating factor (PAF) is a highly active lipid mediator. Intravenous injection can cause arterial blood pressure in the body to decrease, inhibition of myocardial contractile function and increased permeability of the vascular wall. In this study, laser Doppler microcycle microscopy was used to observe the effect of PAF on the rat mesenteric microcirculation. The results showed that intravenous injection of PAF can cause systemic arterial pressure decreased, mesenteric arteriolar and venous blood flow slowed down, vascular caliber