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本实验观察了发热家兔脑脊液(CSF)和血浆中精氨酸加压素(AVP)含量的变化及禁水对家兔内毒素(ET)发热效应的影响。实验结果表明:1.隔区注射AVP可明显抑制家兔ET性发热效应;2.发热组家兔CSF和血浆中AVP含量较正常组明显降低;3.禁水可明显对抗家兔ET性发热效应,其抗热作用与CSF和血浆中AVP含量升高有关;4.禁水也可使正常家兔体温水平下移。上述实验结果提示,AVP可能是家兔体内一种内源性退热物质,同时在正常体温调节中也可能发挥一定的作用。
This experiment was conducted to observe the changes of arginine vasopressin (AVP) content in cerebrospinal fluid (CSF) and plasma of rabbits with fever and the effect of water exclusion on the febrile animal endotoxin (ET) fever effect. The results showed that:1. AVP injected in the septal area can significantly inhibit the febrile ET-induced febrile effects; 2. The levels of CSF and plasma AVP in the rabbits in the fever group were significantly lower than those in the normal group; 3. The thermal effect, its heat resistance and CSF and plasma AVP content increased; 4. Water restrictions can also normal rabbit body temperature levels down. The above experimental results suggest that AVP may be an endogenous antipyretic substance in rabbits and may also play a role in normothermia regulation.