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目的探讨脑钠肽(BNP)与呼吸困难鉴别指数(DDI)在急性呼吸困难患者鉴别诊断中的应用。方法测定89例呼吸困难患者血清BNP水平;同时测定患者的氧分压(PaO2)和呼气峰值流速(PEF),根据Rajesh等创立的公式计算DDI。利用BNP和DDI鉴别心源性和肺源性呼吸困难。结果心源性呼吸困难患者血清BNP水平显著高于肺源性呼吸困难患者与正常对照组(p﹤0.01);肺源性呼吸困难患者DDI显著低于心源性呼吸困难患者与正常对照组(p﹤0.01);两组患者BNP与DDI具有显著的正相关性。结论测定呼吸困难患者血清BNP水平,同时应用DDI能较准确的鉴别心源性呼吸困难和肺源性呼吸困难。
Objective To investigate the application of brain natriuretic peptide (BNP) and differential diagnosis of dyspnea (DDI) in the differential diagnosis of patients with acute dyspnea. Methods Serum BNP levels were measured in 89 patients with dyspnea. The PaO2 and PEF were measured simultaneously. DDI was calculated according to the formula established by Rajesh et al. Identification of cardiogenic and pulmonary dyspnea using BNP and DDI. Results Serum BNP levels in patients with cardiogenic dyspnea were significantly higher than those in patients with pulmonary dyspnea and normal controls (p <0.01). DDI in patients with pulmonary dyspnea was significantly lower than those in patients with cardiogenic dyspnea p <0.01). There was a significant positive correlation between BNP and DDI in both groups. Conclusion The determination of serum BNP levels in patients with dyspnea, while the application of DDI can more accurately identify cardiogenic dyspnea and pulmonary dyspnea.