Background: Laparoscopic liver resection (LLR) is growing in popularity, but the short- and long-term outcome of patients undergoing LLR for hepatocellular carcinoma (HCC) has not yet been established. Methods: A literature search was performed using PubMed, Scopus, and Web of Science (WoS) from cited English and Chinese publications. Clinical and survival parameters were extracted. The search was last conducted in October 2013. After application of selective criteria, 24 remaining original studies with more than 15 patients were analyzed. Results: In the Weste experience, mean operative time was between 150 to 300 minutes, and mean blood loss ranged from 55 to 452 mL. Transfusion was required in all series, ranging from 2.8％ to 50％. The conversion rate ranged from 5％ to 19.4％. Three cases of death were reported. General morbidity rate ranged from 1.5％ to 25％. Specific complications were divided into hemorrhage (2.4％ to 25％), ascites (3.7％to 15.3％), and biliary collection (0.6％ to 5％). Liver insufficiency was reported in two cases. Mean hospital stay ranged from 5.4 to 15 days. In all case-matched studies, LLR was statistically associated with a shorter hospital stay. The 5-year overall survival rate ranged from 55％ to 70％. No trocar-site recurrence was observed. The recurrence rate ranged from 21.4％ to 50％. Comparative studies did not demonstrate any significant difference in terms of recurrence between LLR and open liver resection (OLR). In the Middle Easte experience, mean operative time ranged from 147 to 325 minutes, and mean blood loss ranged from 88 to 808 mL. Transfusion was required, ranging from 1.8％ to 19.2％. The conversion rate ranged from 1.8％ to 18.6％, and four series reported no conversion. There was no mortality. The main specific complication was ascites (1.7％ to 26.6％). A biliary collection was reported in only two series (10.7％ and 13.3％), and only one case of postoperative liver insufficiency was reported. Mean hospital stay ranged from 4 to 11.5 days. Statistically, three comparative studies reported a shorter postoperative hospital stay following LLR versus OLR. The 5-year overall survival rate ranged from 50％ to 76.6％. Comparative studies did not demonstrate any significant difference in terms of overall survival and recurrence rate between LLR and OLR. No trocar-site recurrence was reported. The recurrence rate ranged from 26.9％ to 45.5％, and two series reported no recurrence. Conclusions: Laparoscopic surgery should be considered an acceptable alteative for the treatment of HCC.