论文部分内容阅读
据估计,全世界有三分之一的人口感染过结核杆菌,但其中的90％并未发展成结核病,这归因于有效的Ⅰ型细胞免疫反应。其中受染巨噬细胞分泌IL-12,IL-12可诱导Ⅰ型淋巴细胞分泌IL-2和γ-IFN,而γ-IFN反过来又可激活巨噬细胞,以提高其杀微生物活性。肠道寄生虫感染可诱发Ⅱ型反应,其标志是可分泌IL-4,IL-5,IL-6,IL-10,IL-13,IL-IgE,IL-IgG。体外试验和动物实验表明:Ⅰ型和Ⅱ型反应有交叉抑制作用,γ-IFN抑制Ⅱ型反应,而IL-4抑制Ⅰ型反应。迟发型超敏反应,如结核菌
It is estimated that one third of the world’s population is infected with Mycobacterium tuberculosis, but 90% of them do not develop tuberculosis due to an effective type I cellular immune response. IL-12 and IL-12 can be induced by macrophages, while IL-2 and IFN-γ can be induced by type I lymphocytes. Γ-IFN, in turn, activates macrophages to increase their microbicidal activity. Intestinal parasite infection can induce type II response, the signs of secrete IL-4, IL-5, IL-6, IL-10, IL-13, IL-IgE, IL-IgG. In vitro and animal experiments show that: type Ⅰ and type Ⅱ reaction has a cross-inhibition, γ-IFN inhibition of type Ⅱ response, and IL-4 inhibition of type Ⅰ response. Delayed-type hypersensitivity, such as tuberculosis