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目的提高对非霍奇金淋巴瘤(NHL)伴深静脉血栓(DVT)形成的认识,减少临床漏诊、误诊。方法通过2例病例并结合文献复习,对该病的发生率、发病机制、治疗以及预防进行讨论和分析。结果2例NHL均以下肢水肿为首发症状,经淋巴结病理确诊为滤泡型淋巴瘤(B细胞来源),AnnArbor分期为Ⅳb;超声确诊DVT。接受化疗及抗凝的组合疗法后,1例获得完全缓解(CR),1例部分缓解(PR),DVT均消失。结论DVT可为NHL的首发表现,并可出现于淋巴结肿大前数月,而且NHL伴DVT形成的发生率较低,临床上极易漏诊、误诊。发病机制尚不明确。治疗方法主要为化疗的同时加用抗凝治疗。
Objective To improve the understanding of the formation of non-Hodgkin’s lymphoma (NHL) with deep vein thrombosis (DVT) and reduce the missed diagnosis and misdiagnosis. Methods Through the two cases combined with literature review, the incidence of the disease, pathogenesis, treatment and prevention were discussed and analyzed. Results Two cases of NHL were the first symptom of lower extremity edema. The pathological diagnosis of lymphoma was follicular lymphoma (B cell source). Ann Arbor stage Ⅳb. Ultrasonography was used to diagnose DVT. After receiving combined chemotherapy and anticoagulation therapy, one patient achieved complete remission (CR) and one patient had partial remission (PR), while DVT disappeared. Conclusions DVT may be the first manifestation of NHL, and may appear in the first few months before lymph node enlargement, and the incidence of DVT with NHL is low. It is extremely easy to misdiagnosis and misdiagnosis in clinic. The pathogenesis is not clear. The main treatment for chemotherapy plus anticoagulant therapy.