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加拿大Ｔｒａｖｉｓ等对１９８０～１９９９年北美和欧洲的２８９７１例卵巢癌者进行了研究，其中９６例用铂类化疗后患白血病。他发现接受铂类化疗的卵巢癌病人，患继发性白血病的相对危险为４．０，卡铂和顺铂相对危险为６．５和３．３。白血病发病危险与铂类存在剂量反应关
Travis et al. Studied 28,971 ovarian cancer patients in North America and Europe from 1980 to 1999, of whom 96 had platinum-based chemotherapy for leukemia. He found that patients with ovarian cancer receiving platinum chemotherapy had a relative risk of developing secondary leukemia of 4.0 and those of carboplatin and cisplatin of 6.5 and 3.3. The risk of leukemia and the presence of platinum dose response