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对35例小儿恶性淋巴瘤（ML）经病理学、免疫学、细胞遗传学及超微病理学四个方面进行研究，旨在了解其间的相互联系及其临床意义。结果表明ML免疫分型呈多样化改变，免疫分型与病理类型的恶性程度呈正相关。淋巴结染色体核型异常率高达100％，霍奇金瘤的染色体核型变化较非霍奇金淋巴瘤复杂，并与病理类型有一定相关性。15例ML同时进行了病理及电镜分型诊断，病理亚型诊断答合率80％，电镜亚型诊断符合率93．3％。提示ML是一组高度异质性恶性肿瘤，上述四方面的改变与肿瘤细胞分化密切相关，在病理分型的基础上结合电镜检查，可提高ML各亚型分类的准确性。
Thirty-five cases of pediatric malignant lymphoma (ML) were studied by pathology, immunology, cytogenetics and ultrastructural pathology in order to understand their interrelation and clinical significance. The results showed that the diversity of immunological typing of ML was changed, and the immunophenotype was positively correlated with the malignancy of the pathological type. Lymph node chromosome karyotype abnormalities as high as 100%, Hodgkin’s tumor chromosome karyotype than non-Hodgkin’s lymphoma complex, and the pathological type has some relevance. Fifteen cases of ML diagnosed by pathology and electron microscopy at the same time, pathological subtype diagnosis of 80% response rate, subtype of electron microscopy diagnosis coincidence rate of 93.3%. These results suggest that ML is a group of highly heterogeneous malignant tumors. The above four changes are closely related to tumor cell differentiation. Combined with electron microscopy on the basis of pathological classification, ML can improve the accuracy of ML subtypes classification.