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采用乳化-化学交联法制备了盐酸环丙沙星-ε-聚赖氨酸(CH-PL)微球。利用扫描电镜、红外光谱和ZetasizeNano ZS对载药微球进行表征,并考察了CH-PL微球在0.1mol/L HCl(pH=1.2)溶液中的释药行为以及不同交联剂用量对载药微球释药速率的影响。结果表明:成功制备了球形圆整、分散性好、平均粒径约为15μm的CH-PL微球,其最大载药量和包封率分别为5.1%和42.8%;CH-PL微球具有良好的缓释效果,释药过程符合Higuichi机制,且微球的释药速率随交联剂用量的增加而变慢。
Ciprofloxacin-ε-polylysine hydrochloride (CH-PL) microspheres were prepared by emulsion-chemical cross-linking method. The microspheres were characterized by scanning electron microscopy, infrared spectroscopy and ZetasizeNano ZS. The release behavior of CH-PL microspheres in 0.1 mol / L HCl (pH = 1.2) solution and the effect of different crosslinking agents on Effect of Drug Delivery on Microspheres. The results showed that CH-PL microspheres with spherical shape and good dispersity and average particle size of about 15 μm were successfully prepared. The maximum drug loading and entrapment efficiency of CH-PL microspheres were 5.1% and 42.8% Good sustained-release effect, release process in line with the Higuichi mechanism, and the release rate of microspheres with the crosslinking agent dosage increases.