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阿司匹林是临床常用的解热镇痛药,目前国内本品的剂型主要为肠溶片,有胃肠道不良反应。阿司匹林口腔崩解片剂型,可使崩解时间显著缩短,溶出速度提高,吸收快,提高生物利用度。通过阿司匹林口腔崩解片进行了Beagle犬体内药物动力学研究,建立阿司匹林口腔崩解片在Beagle犬血浆中的HPLC-UV测定方法,采用自身对照交叉试验设计方法,以阿司匹林普通片为参比制剂,进行了阿司匹林口腔崩解片的单剂量试验。表明课题阿司匹林口崩片的研制及所建立的溶出度测定方法在试验动物的评价水平上科学合理。
Aspirin is commonly used in clinical antipyretic analgesics, the current domestic dosage form is mainly enteric coated tablets, gastrointestinal adverse reactions. Aspirin orally disintegrating tablet form, can significantly reduce the disintegration time, dissolution rate increased, fast absorption, improve bioavailability. By aspirin orally disintegrating tablets in vivo Beagle dog pharmacokinetic studies to establish aspirin orally disintegrating tablets in Beagle dog plasma HPLC-UV determination method using self-control cross-test design method to aspirin tablets as a reference formulation , A single-dose test of aspirin orally disintegrating tablets was performed. The results showed that the development of aspirin orally disintegrating tablets and the established dissolution testing method were scientific and reasonable in the evaluation of experimental animals.