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目的探讨心脏肌钙蛋白Ⅰ (cTnⅠ )对急性一氧化碳 (CO)中毒患者伴有心肌细胞损伤的诊断价值。方法 :应用免疫化学发光法 ,测定 31例急性CO中毒患者血清cTnⅠ含量 ,另设 30例作健康对照组。结果 :中度和重度急性CO中毒患者 ,其血清cTnⅠ水平明显升高 (大于 0 .4ug/L) ,提示伴有心肌细胞损伤 ,轻、中、重 ,不同程度CO中毒组间伴有心肌细胞损伤的百分率间有显著统计学差异 (P <0 .0 1)。结论 :心脏肌钙蛋白Ⅰ可以作为判断急性CO中毒伴有心肌细胞损伤的指标。
Objective To investigate the diagnostic value of cardiac troponin Ⅰ (cTn Ⅰ) in the injury of myocardial cells in patients with acute carbon monoxide (CO) poisoning. Methods: The serum levels of cTnⅠ in 31 patients with acute CO poisoning were determined by immunochemiluminescence assay. Another 30 patients were used as healthy control group. Results: Serum levels of cTnI were significantly elevated in patients with moderate or severe acute CO poisoning (greater than 0.4ug / L), which suggested that myocardial injury was associated with mild or moderate or severe CO poisoning. The percentages of injury were significantly different (P <0.01). Conclusion: Cardiac troponin Ⅰ can be used as an indicator of acute myocardial injury associated with CO poisoning.