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作者用ABC法和D-PAP法检测了59例慢性乙型肝炎患者肝内HBcAg及血清HBV-DNA、抗-HBe。结果,肝内HBcAg的检出和含量与肝损伤呈负相关趋势,提示CAH肝损伤程度不直接与HBV复制有关,且表明血清HBV-DNA能很好地反映肝内HBcAg存在情况,在血清中已出现抗-HBe的病人中可检出肝内HBcAg(39％)及血清HBV-DNA(45％),所以不能认为抗-HBe是HBV复制停止及传染性减弱的指标。
The authors used ABC method and D-PAP method to detect the intrahepatic HBcAg and serum HBV-DNA and anti-HBe in 59 patients with chronic hepatitis B. As a result, the detection and content of HBcAg in liver were negatively correlated with liver injury, suggesting that the degree of liver injury in CAH is not directly related to HBV replication, and the serum HBV-DNA can well reflect the presence of intrahepatic HBcAg in serum HBcAg (39%) and serum HBV-DNA (45%) can be detected in patients with anti-HBe, so anti-HBe can not be considered as an indicator of cessation of HBV replication and decreased infectivity.