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目的：了解结核病短程化疗方案所用药物的不良反应发生情况及其对结核病防治工作的影响.方法：随访及查阅应用短程化疗方案的痰涂片阳性（简称涂阳）肺结核病历1394例，资料经计算机处理分析。结果：对使用2HRZE／4HR.HRZES／6HRE短程化疗方案的1394例涂阳肺结核病人进行了调查，发现不良反应发生率为28.26％。患者的性别、年龄、用药种类、强化期长短，对不良反应的发生均有影响。主要不良反应为：胃肠道反应25．05％，过敏反应20．24％，关节损害16．28％，中枢神经系症状13．65％，肝损害2、68％等。这些抗结核药物的不良反应发生率分别为：吡嗪酰胺20．24％，利福平19．12％，雷米封15．26％，乙胺丁醇12、63％，链霉素4．68％。结论：由于短程化疗方案药物剂量偏大，不良反应发生率较高，对结核病治疗带来了一定困难。建议在方案实施过程中，加强药物不良反应的监测与处理。
Objective: To understand the adverse reactions of tuberculosis and its impact on the prevention and treatment of tuberculosis.Methods: Follow-up and access to 1394 cases of sputum smear-positive (smear-positive) pulmonary tuberculosis with short-course chemotherapy were followed up and the data were analyzed by computer Processing analysis. Results: A total of 1394 smear positive pulmonary tuberculosis patients treated with the 2HRZE / 4HR.HRZES / 6HRE short-course chemotherapy regimen were investigated and the incidence of adverse reactions was found to be 28.26%. The patient’s gender, age, type of medication, duration of intensive treatment have an impact on the occurrence of adverse reactions. The main adverse reactions were: gastrointestinal reaction 25.05%, allergic reaction 20.24%, joint damage 16.28%, central nervous system symptoms 13.65%, liver damage 2,68%. The adverse reactions of these anti-TB drugs were: pyrazinamide 20.24%, rifampicin 19.12%, Remy seal 15.26%, ethambutol 12, 63%, streptomycin 4. 68%. Conclusion: Due to the large dosage of drug in short-course chemotherapy, the incidence of adverse reactions is high, which brings some difficulties in the treatment of tuberculosis. It is suggested that in the implementation of the program, we should strengthen the monitoring and treatment of adverse drug reactions.