目的:探索来曲唑(LE)联合hMG促排卵方案应用于冻融胚胎移植(FET)内膜准备的临床效果与预后因素。方法:月经第3日起口服LE连续3～5d,第10日起超声监测,若优势卵泡<14mm,则注射hMG150IU,隔日诱发排卵后92～152h解冻第3～5日胚胎。结果:共纳入119名患者,完成124个FET周期,临床妊娠率为42.7%(53/124),种植率为22.5%(70/311)。妊娠组的年龄显著小于非妊娠组(P<0.05);黄体支持组临床妊娠率为50.6%(45/89),显著高于无黄体支持组的22.9%(8/35)(P<0.01)。结论:在选择性的患者群体中,FET周期中用LE联合hMG准备内膜方法简单可行,年龄、是否采用黄体支持是影响预后的重要因素。 Objective: To explore the clinical effects and prognostic factors of letrozole (LE) in combination with hMG ovulation induction in endometrial preparation of frozen-thawed embryo transfer (FET). Methods: The third day after menstruation, oral LE for 3 ~ 5d, the 10th day ultrasound monitoring, if the dominant follicle <14mm, hMG150IU injection, the next day after ovulation induced 92 ~ 152h thaw 3 ~ 5 embryos. Results: A total of 119 patients were enrolled and 124 FET cycles were completed. The clinical pregnancy rate was 42.7% (53/124) and the implantation rate was 22.5% (70/311). The pregnancy rate in pregnancy group was significantly lower than that in non-pregnant group (P <0.05). The clinical pregnancy rate in luteal support group was 50.6% (45/89), significantly higher than that in non-luteal group (22.9%, 8/35) . CONCLUSIONS: In a selective patient population, the combination of LE with hMG in the FET cycle is simple and feasible, and the age, and whether or not luteal support is used, are important prognostic factors.