对有新生儿溶血病史、不明原因流产、早产、死胎史夫妇216对进行了ABO、Rh 血型鉴定,120对夫妇血型不合的O型孕妇进行了IgG 抗A(B)抗人球蛋白效价测定,IgG 抗A(B)效价≥1:64者65例,占54.1%。在我院已分娩的54例中,新生儿溶血病发病29例(53.7%)。发病率随母亲血清中免疫性抗体效价升高而上升,当IgG 抗A(B)≥1:64时,发病率为66.6%;当IgG 抗A(B)≥1:128时,小儿全部发病。孕期血型抗体测定对新生儿溶血病产前诊断、预防及治疗有一定的意义。 A total of 216 pairs of patients with history of newborn hemolytic disease, unexplained abortion, premature birth and stillborn fetus were subjected to ABO and Rh blood group identification and anti-human IgG titer of anti-A (B) IgG of 120 pregnant women with O-type incompatibility. , IgG anti-A (B) titer ≥ 1: 64 in 65 cases, accounting for 54.1%. In our hospital has 54 cases of childbirth, hemolytic disease in 29 cases (53.7%). The incidence increased with the rise of the titer of the immune antibody in the mother’s serum, with an incidence of 66.6% when IgG anti-A (B) ≥1: 64; when the IgG anti-A Disease. Determination of blood group during pregnancy prenatal diagnosis, prevention and treatment of hemolytic disease of some significance.